Can I Run 2 sets of speakers at once?

The OP probably wants to run both in two rooms together. Tube amps are usually ok with 4 ohms or less.

In the same room not advisable, the speakers will cause issues with comb filtering.

To be safe you can hook up the speakers in series! 

Wiring speakers in series involves connecting the positive terminal of one speaker to the negative terminal of the next, creating a single path for the audio signal while increasing total impedance for safe amplifier operation

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What Series Wiring Means

In a series configuration, all speakers are connected in a chain:

• Positive (+) of the amplifier → positive (+) of the first speaker

• Negative (−) of the first speaker → positive (+) of the second speaker

• Continue this pattern for all additional speakers

• Negative (−) of the last speaker → negative (−) of the amplifier

This setup ensures each speaker receives the same current and the total impedance is the sum of individual speaker impedances. For example, two 8-ohm speakers wired in series result in a total impedance of 16 ohms, and three 8-ohm speakers give a total of 24 ohms 

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Not in the same room!!