Speaker Help Please: Floorstanders around $1Ok to fill very large space with no sub

To fill the large room with ample bass and an engaging midrange voices:

+1 GoldenEar Triton Reference - very generous powered bass, fantastic soundstage, engaging musical sound. Would also work well in home theater

+1 Klipsch Khorn or La Scala - very high efficiency ideal for warm tube amplification which would give warm midrange - magical with voices. Very horn quick and effortless, but soundstage not a priority 

+1 Pure Audio Project

Other floorstanders might also work in the large space, but will need strong bass drivers since no subwoofers.

@bigasscab honestly I have never seen a more hodgepodge collection of answers.  I think you are better off ignoring most every answer here and just go listen to some.  A few are great speakers.  Even an audio show in small rooms will give you ideas about how speakers  / electronics fill a room.  I do agree two subs is the way to go, even with large cones and big cabinets.  They always improve things.   Don't skimp on the electronics.  But you do have to decide on type, as about 5 types have been recommended here:  360 degree emitters (ohm, mbl) electrostatic panels, horns,  sealed and ported designs.  I would stick with conventional designs, ports or not, and consider two subs.

A lot of great suggestions.  Suggest using a local dealer that will let your friend buy and try and return for another pair if not happy.  That or a manufacturer or online that will let him buy and try and return for no or little cost.  I agree with the Perlisten if it was my money with that room.  I would also look at Arendal 1528 towers.  I think they will need subs if they are serious as you say they are about music. 

second hand:

Revel Salon 2

Revel F328Be

maybe the Kef Reference 3 Meta or the Blade 2 (though they might be too small)

new:

Polk L800

Klipsch Cornwall IV.  Heard them in Hope vs Heresy, LaScala, KHorn and Jubilee, mix of gear, McIntosh mostly. Big expansive sound, with deep, warm, powerful bass.  I have Forte IIIs at home, Cornwall is the bass king with classic Klipsch midrange and top end.