rodents getting into speakers via speaker ports

They have a peppermint spray  spiders, mice hate  ,spray a bit on 1 x a week.

I'd be more worried when the venomous snake follows the mouse in to the Speaker's enclosure.

The mouse problem will be left as a ball of a hard fury mass within. 

I had an infestation of small, really fast spiders in my listening room. Finally after months I figured out they were living and breeding on the underside of both my Magico A3 speakers. No ports on the Magicos, but enough space created by their legs to create a breeding ground. I mean, who vacuums or looks under their speakers for Spiders from Mars.

Similarly, auto manufacturers often leave unsealed openings that invite mice into cars. I currently have mousetraps under the seats and have caught at least one intruder in our Toyota Corolla thus far. 

Sounds like some of you folks need to contract with a good pest control company.