I mainly use headphones when I'm moving around, either in the house or outside. I miss the depth effects that 2-speaker systems provide, even though my headphones/earbuds can hint at those effects.
I also use earbuds when I'm recording, mixing and mastering my own original music. I do a check with my main speakers before final mastering, mostly to make sure the instruments are panned the way I want them--speakers give a different perspective on that than headphones.