You have received thoughtful replies. It is like anything else you might buy used, including a car. Evaluate the seller. Do they seem to be someone who takes care of their equipment and generally has their s__t together? Also, is the sub a brand that is still commonly supported by the manufacturer.
I own three subs that I purchased used. All of them are used almost daily for the past 5 to 15 years. Two have list prices over $5K. They all work and sound great. One of them needed a repair to the amplifier that the manufacturer took care of promptly and informed me the issue was a design issue so I purchased a spare amplifier for the other sub (two of them are the same) in case I had amplifier problems with that one (original amp still works fine). In conclusion, buying a high quality product, that is still supported by the manufacturer, and from a careful seller, is really no different than anything else related to audio that we purchase used, IME,