It's an interesting question. Ten or twenty years ago there was a fad for what I call "gutbucket" amps, old PA or organ amps hacked up, spray painted weird colors and purporting to have a "magical" sound. Most of them were junk. But there are some very good boutique amp builders out there today who can use high-end components and interesting designs that aren't cost-efficient for a large manufacturer. In fact, some boutique amps from the 80's, 90's and even 2000's have achieved legendary status and command pretty good prices.
First of all, I think that you have to have some experience, enough to know what you want. You've determined that CJ or Cary or Rogue or McIntosh or whoever aren't offering what you crave. You're looking for something really special. SNS makes a very valid point that for truly special SET amps, you're almost forced to seek a bespoke amp because there are so few "commercial" offerings out there.
I think there are a few things that need to be considered.
- Resale value. Best not to think about that. If it's a really well-made piece, and you find after a time that you want to move on, chances are someone will want it. But bespoke amps are not for eternal swappers.
- Build quality. It should be obvious even to the untrained eye, but you can always ask others to take a look and see what they think. A photo of the underside should really be part of the buying process.
- Circuit design. Will ANYONE else down the road be able to figure it out? If not, you might want to stay away.
- Support. Will the builder stand behind the amp, come what may?
- Schematic. Will the builder provide a schematic? The truth is, there's almost nothing new under the sun when it comes to tubes. And really, what's the big secret? Are thousands of DIYers going to copy your amp?
I build Williamson amplifiers. That's all I build, but I find them fascinating because every build offers new challenges and rewards--a different output tube, a different output transformer, a new trick in the power supply. I'm like the character in the Inspector Wallender mysteries who only paints one painting, over and over. ;-) But here's the thing: A Williamson is a Williamson. Any tech, or even a skilled amateur, can diagnose and repair it. I provide a schematic. You want to copy it? Be my guest! I authored a thread over at diyaudioprojects.com showing you how to do it, and even posted the gerbers for the PCBs I had designed. (BTW, there's NOTHING wrong with a quality PCB.)
My point is that boutique amps can be very satisfying if there's ample documentation and communication. But there's no question that it's a risk if you have no idea *what you're looking for.*

