Should the power be off every time changing cables?


I’m experimenting different IC and speaker cables.
Powering on and off to power amp, preamp, and other components each time changing cables is really bothering, because I need to wait 10 minutes or so between power on an offs.
I wonder I still need to turn off the power amp when I change IC cables between preamp and components. 
What kinds of cables can be changed with power amp on?
 I have a Plinius power amp and preamp.
Thx
128x128ihcho
The amplifier is definitely a component you want to keep off during any cable changes. It and the speakers are the most likely to have ballistic failures (as in, things fly) if you do something bad.
All other gear will be OK, with low voltages and low currents.
@almarg  and others...   To clarify, component off or system off?  If the component (for example Pre to Amp), then the Pre or the Amp or Both? Thanks.