Ortofon 2M Red and Denon 110 Is there a big difference in sound quality??

@sunnyjim why do you want to try low budget high output MC if you can just find some killer vintage MM (used) for much more reasonable price? Low budget MC cartridges are not neutrial, they are colored. If you don’t like those Ortofons (i don’t like them) try the AT20SLa which is great for the money. The AT-ML170 is amazing. I hope you already checked this TAS article? The alternative to the Ortofon is not the DENON HOMC, but just a decent MM with advanced stylus profile and cantilever. I’ve been using HOMC Dynavector DV30a and we have discussed here why the HOMC are inferior to LOMC. But the best MM beats them all. Last month i have shipped another spare AT-ML170 to audiophile in Texas, the guy is into LOMC sound, yesterday he reported back: " this no doubt is the BEST cartridge I’ve had in my system by Far!" I agree, the AT-ML180 that i use myself is just slightly better.

And why the AT20SLa is great too? Because the styli are still available. This is high compliance MM. 

Denon  does miss some detail   but is more musical than  the red , easier to listen to . I ran both side by side in two TT setup for a few months .Jazz
mostly .

I used to have a Pro-Ject Debut with a 2M Red and replaced it with the Denon DL-110.  Huge improvement.  Price/performance of the Denon is superb.

Lot's of other choices though as @chakster mentioned.

Good luck.

@chakster ...couldn’t be that your touting these cartridges because you have them for sale? The links are clearly to your ads on another site. Shame on you...