@bartsw
Yet, we choose not to listen to music with just subwoofers instead of speakers. ... It also implies paying up to $$$ more for 1000 feet of RCA cables that are subject to EMI/RFI and running them all over the room is superior to running a 3 feet lamp cord to a speaker, which isn't subject to EMI/RFI within the audible range. There isn't a one is better than the other here
Hard to know where to start on this twaddle! If a subwoofer could be made to handle the entire audible frequency range, that would be excellent. But that would turn if from a subwoofer into a full-range driver. Physics stands in the way, at least for conventional dynamic drivers fabricated from cones and electromagnets.
Quad has made full-range drivers for over 40 years, but they are electrostatic panel speakers using featherweight membranes. They also use sophisticated delay lines to emulate the ideal of a point source of sound.
Other manufacturers like KEF and Fyne address the point source of sound ideal, using dynamic drivers with the tweeters concentrically placed inside their woofers.
With my preferred wiring suggestion, the OP would only need 1000 feet of RCA cable if his electronics were 250 feet from his subs. Unlikely. At a separation of 6 feet, he would need a more reasonable 24 feet, one fortieth of what you suggest.
As far as EMI is concerned, I would prefer to run balanced interconnect cables but KEF has made no provision for balanced connections. Presumably they don't see sufficient benefit. Note that EMI covers the entire electromagnetic spectrum, of which RFI is just a small part.
The OP's SoulNote amplifier is deliberately designed without negative feedback. This means it measures poorly in conventional frequency-based distortion tests. It is done to get the highest possible fidelity to the transient waveform in the time domain, which is where music actually resides.
The OP can easily try both wiring options to see which is better for the FIDELITY in his thread title.