emi and jitter can both cause harshness in the rendered audio signal -- in the treble and mids -- and give a sense of lack of focus, a loss of spatial cues, imaging specificity, and weak bass
regardless if a dac is asynchronous or not, the signal needs to get from a to b -- the clock signal is but a small subset of what is being relayed by the cable -- and a poor cable can certainly harm the signal and as a result, make the music sound worse, subtly or not so subtly
each system has different resolution, each listener has different hearing acuity... there is simply no shortcut to trying different cables and setups, to see if it makes a noticeable or meaningful difference in YOUR system
same thing with everything -- equipment, room setup, cables, front end digital isolation, linear power supplies, cartridge and tt setup, mechanical isolation, and so on and on

