@pcrhkr wrote:
As far as woofer size, the effective radiated area of 2 six inch woofers will be about the same as a 12" woofer.
No, dual 6" woofers only cover half the displacement of a 12" woofer. There’s a significant difference.
My experience is that a larger woofer will give more slam, hit, kick, in a 12" woofer vs two 6". However, the two 6" will likely respond more quickly in music dynamics because there is less mass to control.
In this case a 12" woofer would first and foremost move more air, i.e.: twice of that produced by dual 6" woofers. The perceived difference between these two scenarios would depend on several factors, but certainly the 12" woofer must be expected to have more impact, albeit not necessarily how one would imagine it.
What I’ve found is that I prefer a single larger woofer vs. several smaller ones, however a comparison would have to factor in that a woofer of, say, 15" is typically a higher efficiency variant (you don’t see many 15" low eff. "Hi-Fi" woofers), and thus it’s likely used differently than an array of low fs woofers with all that implies sonically.
As a general observation though I tend to find larger woofers (vs. several smaller) to be more tuneful, articulate and less conspicuous in the mix. Many may believe a 15" woofer to be this crazy beast that puts out loads of bass compared to a pair of 6.5 or 8" woofers, but the perceived outcome is actually quite different, I find.

