I have XLR cables with pure silver wiring, so yes, I'd use it, but honestly it is rare that we need to in a home.
There have been cases when I was at a show in NY and we had poorly shielded RCA cables and we were picking up a local radio station and I would have loved to have XLR's for this... but alas.
At home, with short runs, the one major benefit IMHO is the locking nature of the plugs!

