I've been having a similar problem lately. I can't decide if it's tubes or a bad connection at the speakers. I roll tubes often, trying different combinations of 6sn7's. My preamp uses 4. I recently upgraded speaker cables to Blue Jean Canare and have had some issues with connections. I had them made with spades at the speaker end and locking banana at the amp end. I had trouble keeping the spades tight at the speaker end. The spades are very large and very smooth/slick/slippery. I had them spin around and contact each other which made quite a noise. I have since connected the spades to my amps and they stay tight and can't possibly touch. I've had some issues at the speaker end with loosening of the locking bananas. They are an odd fit to the old AR9 binding posts and I do have one loose binding post.
After the switch of bananas to speaker end, I started to hear popping and crackling again, not the terrible loud problem I had before but similar. Not a dead short but possible loss of connection. Still sorting out if it's a tube issue or a cable/speaker connection issue. I got through a few hours of listening with no problems before it started for the second time. Each time has been with GE/KenRad 6sn7 side getter tubes, two different sets. No idea if they are the problem yet or not. Testing is making me more nervous with each problem that occurs. Anyway, will post if I figure it out. I have another pair of speakers to try also, which might help. I wouldn't think one loose binding post could be so much trouble but maybe it could.

