Speaker Choice ?

Well obviously "best" will be very subjective and highly debatable.
Perhaps you could tell us what kind of music you listen to, what your sonic priorities are, how loud you usually listen, etc. This may help with some recommendations.

Cheers,
John

Along with Jmc's post, I'd add that most. Speakers will work in that room. My room is 22 wide, 18 deep with cathedral ceilings and I use 5 1/2 Fostex full range drivers with a couple of 8in subs. Sound easily fills the room and the kitchen/dining room behind the front wall. I listen to mostly vintage rock and its offspring. A 35 watt tube amp drives my 95db speakers.

I don't know that I agree that "most speakers will work in that room". That is a very large room, and will take some fairly efficient full range speakers to fill it with music.

You can find excellent Dunlavy SC-Vs for under 5K and they would be stunning in a room this size. There are a lot of great speakers that do some things very well, but I have not heard any speakers, short of 20K+, that does everything as well as the Dunlavy(s).