Long run balanced interconnects


I am looking at a situation that may require that I do a long run (25 feet) of balanced cable.  Should I expect there to be a degradation on sound quality if the long run was between the phono amp and the preamp versus the preamp and the speakers?  Any other advice regarding long runs of balanced cables?
chilli42
You say preamp and speakers are they active speakers? If so I  would make the long run there
What is the preamp?  Also, it may be helpful for us to know the make and model of the power amp.

Regards,
-- Al