It will make a difference, but how significant is hard to predict. If your arm allows for height adjustment to set the VTA, try lowering the arm to reduce sibilance.
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Depends on what angle your stylus is mounted on the cantilever compared to your last cart. The angle can vary even with the same brand/ model. As suggested above try lowering the back of the arm to reduce sibilance. Also you may need to try a different loading of this cartridge than the last one you used. Try lowering (numerically) the loading to see if that helps.
I tried a few VTA settings to no avail. So I decided to recheck my alignment, and take my time. You see, I can can set up a Denon DL301mk2 - Dyna 10x5 and a few others lickity split! But I found out how critical a severe stylus shape can be to align. Close is not good enough! The sibilance is now gone.