I had an awful experience with an S400. I bought tested, aftermarket tubes from reputable resellers because the original VTL tubes (6550s) that came with the amplifier got nowhere near the 'advertised' (website) and in the S400 manual, 'average' life of 3,000 hours. And they were twice the price. The aftermarket tubes were slightly but not much better in terms of reliability. Thinking this was an amplifier issue the local distributor went back and forth with VTL who insisted that only VTL tubes be used. I bought a matched set (12x KT88s) only to have 8x of them fail in less than 1500 hours.
The KT88s were more detailed and dynamic but less 'flesh-on-the-bone' compared to the 6550s.
I sold the S400 and note VTL removed statements on their website referring to their autobias function delivering the 3,000 hours average.
If you don't mind VTL not offering support because you're not using their tubes, then go for it!
YMMV.

