I think a lot depends on system matching too?
agree that tube selection is like any other component, including cables -- should be chosen carefully to synergize with the rest of the setup to achieve the sonic attributes desired
this having been said, i have found that specific vacuum tube sonic traits remain remarkably consistent and audible in well designed gear, but is particularly noticeable in simpler (sometimes older) circuit designs that use the tube as a more essential part of the musical production (i.e. in the i/v amplification section, as opposed to in a follower/buffer application) -- so one should always thoroughly understand what each tube in a piece of gear is actually doing
in a vac pa90c amp set for instance, the difference between an iec mitcham mullard 12ax7 in the first position input/phase splitter spot vs a heerleen amperex one is immediately audible

