To @jngrausr the V12R is a unique amplifier and I regret selling mine. A really nice gentlemen bought it from me, and he tried with this his friends' speakers too. A few others on this forum have explored running the amp with fewer tubes as well, removing all the tubes except a few pairs on each side.
Fuses, and Biasing:
My local 50yr in business tech repair friend helped me, and we had the former amplifier engineer at Cary Audio on calls together a few times to address fuse-blow issues once, and biasing. Two things came about.
Bias, per side:
Bias at 260-280ma per side [as stated in the old non-updated manual] was deemed as being "too high, and unnecessarily burning up the EL34 tubes prematurely."
Fix: back the bias down to a low of 200ma to a high of 230ma per side. "no need to go higher" according to my local tech friend. Sounds good in this range, saves your EL34 tubes.
Fuses:
The Cary tech at that time had restored a few V12Rs that came in on trade, and stated if the EL34 tubes are all good, the power transformers are good, then running a 5am slow blow fuse was okay, and the original manual use to show 4amp IIRC.
Procedure:
If you can try the procedure above, and rule out the transformers are okay, and don't blow the as a result of transformer deterioration, next is to test the tubes. That amplifier made me come close to buying my own tube tester rig and instead I'd rely on my local tech to test tubes for me. The entire time I owned my V12R, I ran the same EL34 tubes over several years. Maybe reach out to a local shop/tech, and have all your EL34 tubes and little input tubes tested first, if you are not sure.
Good Luck.

