Generally, the more subs, the better the sound, but there are constraints:
- Geometry of the room
- Practicality of certain locations
You can get a good feel for sub placement by using the calculators mentioned by @deep_333 and others, or REW's room simulator.
I've been working on the system for a new build's living room. REW simulations showed me that, for the practical locations for subwoofers in my space, two worked just about as good as three. Also, the simulations show that, with the placement of those two subs, high-passing my mains should result in better sound than letting them run full-signal.
The only way to know for sure is to place the subs in the real space, but good simulations can help narrow the possibilities. In my case, it allowed me to be sensible about where to run conduits through the ceiling for subwoofer cables, which will lead to a much cleaner-looking room.
I'll also add another +1 for Rythmik subs. The continuous phase control is critical, and as mentioned above, the sound is tight and defined.

