I have all three units.
From a potentially audible standpoint, the one argument for the Ultra is that it has USB output to an external DAC (along with optical & coax) while the Pro and Pro Plus devices only support optical & coax. While I don't find any difference between the outputs, there are others who have a strong preference one way or the other.
Which one I use in what system ties more to features. I have the Ultra in my main system and like the screen and extra inputs. I use the Pro in a headphone system where the amp has its own DAC. And I use the Pro Plus in a second system where a touch screen wouldn't be visible or easily used.
Your mileage may vary.

