I had the Pontus 15th into a balanced input for Woo Audio WA33 and it sounds wonderful. I am now waiting for LTA Aero DAC order for that system.
I would say the single ended out is 10% to 20% less than the balanced out with Denafrips depending on the equipment connected to.
In comparison the Holo Audio Cyan 2 is hard to tell a difference, Maybe single ended out is 5% less than balanced out.
The Holo Audio DAC has a circuit after the R2R ladders to convert balanced to single ended so both sides of the ladders are still used. Denafrips just taps pin 3 of the balanced out to the single ended connection so only half ladder is used.
As for the connections I2S is the best on Denafrips. USB circuit is not as good in my experience. Maybe 10% less.

