Remote and Portable Data is so compact and affordable, and USB 3.0 is very fast.
I keep only Operating System and Programs on the internal start up drive. All data is on a portable drive, USB 3.0 is so fast you think it’s an internal drive. And, after the large initial backup, incremental updates are quick.
I have two identical external hard drives, one connected USB 3.0 to my Desktop Computer for all data, and I keep the second backup one in the trunk of my car which I park in my inactive residential street at the end of the driveway.
Weekly backup of new/modified files.
If there is a house fire, hopefully they will put it out before my car is destroyed.
I really should keep backup copies of my software somewhere safe.
When I was running my business from home, more critical client files, and external drives were neither afordable or compact, and SCSI chains were involved, I kept my backup drive inside my neighbor’s home across the street, and I kept her backup here. We reminded each other to backup weekly.
It’s not if a drive will die, it;s when, but both won’t die at the same time.
Another advantage, I can take my primary portable drive with my laptop, and have the latest files anywhere anytime, and do the backup anywhere anytime, just don't risk keeping them both in the same place often.