Sure, they could "work", but why do you "need" high sensitivity speakers and why is something so big your first choice? How much do you care about imaging and soundstage, and how will you control the bass?
It would be helpful to know what electronics you're using and what type of sound you like - warm, detailed, neutral...
For a room of that size, I would seriously consider the Klipsch RP-600M II and a small sub. I heard them recently at a friend's house and was quite surprised by how good they sounded. They should image better in that small space and can create a large soundstage.
Unless you're running an amp with only a couple of watts, I would lean towards smaller monitor type speakers and a small sub - one of the LS3/5A variants like Harbeth P3ESR, Falcon, Graham Audio etc. would work much better in that space.
I have a pair of Klipsch Quartets in my bedroom, which is similar in size to the room you describe. They "work", but fill the entire room with sound and don't do any of the magic that smaller monitors do.