@chayro Great question, upgrade a DAC vs DDC to get away from USB.
My opinion is get away from USB.
I have an Innuos Statement Nextgen with both USB and Ethernet output. The Ethernet is hands down superior even with a FTA Sinope USB Cable. I sent my Lampizator Goldengate back to Poland for upgrades including the new USB board, the S/PDIF is still superior with a relatively inexpensive BNC cable. I am trying a Network Acoustics AES next week and expect it to be even better.
To get from the Statements Ethernet output to BNC input on the Goldengate I convert the Ethernet to Fiber with a Sonore OpticalModule then convert the Fiber to USB with a Sonore SignatureRendu then the USB to BNC with an Antipodes S20 and then BNC to the Goldengate DAC.
It is easily better than direct USB from the Statement to the Goldengate. I have tried the USB from the Statement to the Antipodes DDC and it is inferior to the Ethernet chain.
The Statement is touted to have a very good USB and the new USB on the Lampizator is supposed to be much better than their old USB, but neither can beat Ethernet out or BNC input.
I have used I2S with mixed results, it was worse than USB in one system and better in another. Like USB there are both good and bad implementations. I found the IS2 cable really mattered and spent more on it than the Iris DDC I used to use, but overall was never really satisfied with the sound of the I2S set up on the Iris. I regret never trying the S/PDIF on the Iris to the TerminatorPlus DAC. I am happy with my set up now but if and when I need to change I will audition a direct Ethernet between Streamer and DAC.