@yyzsantabarbara All pin configurable ddc like my Denafrips Gaia will work with any dac with I2S input, dac doesn't need to be pin configurable although I think most are.
Per interfaces, there are some proprietary interfaces out there, Wadax, Taiko, Auralic are a few, limitations of usb well known. This doesn't mean usb can't provide quality sound, I was content with a variety of optimized usb interfaces over the years, this until high quality implementation of I2S. Also, with all the variability available with interfaces not all I2S will be superior to usb, thing is I2S requires absolutely no optimization within dac, I2S is native signal path in dacs, usb requires much optimization within dacs to perform to it's highest potential.
As @ghdprentice pointed out streamers extremely important component in streaming chain, some claim it more important than dac. I wouldn't argue with this, safe to say both extremely important. As for streamers importance for interfaces, the output from streamer equally important to input on dac, crap out will defeat the purpose of any optimized input. This part of the appeal of a ddc, some also help to optimize streamer outs.
Some manufacturers love to brag about galvanic isolation with their usb implementation, this is bare minimum for optimized usb, clocking and power supplies to those clocks is of utmost importance with any interface.

