Nodes are another factor where having the subs in the same location as the mids/tweeters can cause issues. But to be sure dialing in the correct placement of separate subs can be frustrating as well, not to mention speaker cable placement and ability to have the subs in a user friendly location.
All in all, I worked it out to my satisfaction and wouldn't change anything. The balance in the spectrum built in by the manufacturer overcomes the downsides, at least in my experience.

