As a suggestion; unplug the unit for about 3 minutes.See if that helps.-----Also another trick that has worked: Reverse the battery direction.Push any one button--Then reinsert the batteries in the correct direction.
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Make sure your remote's infrared transmission lenses and your preamps sensor surface are clean. Also, too much ambient infrared light can obscure or confuse the preamps reception of the remote's signal. I assume your preamp is never starved for correct voltage -- a low voltage supply (brown out?) could impact the sensor circuit. Otherwise, sounds like you should consider sending the remote and preamp in for service. Good luck.