Please define

What term are you speaking of?

If you're referring to listener fatigue, it's a term I personally associate with a very forward, in-your-face type of sound. When the soundstage is pushed aggressively and artificially toward me, I lose all sense of background, sublety, microdynamics, and so on. Over time I find that such sonics become "fatiguing" to listen to.

Your mileage may vary, reasonable minds may differ, your gear and your ear, etc.

I find it really depends to a great extent on the music you are playing and the mood you are in. Sometimes I want it face forward sometimes I just want it sweet. I also find that having a couple of different systems help!! Volume by the way is critical. Your hearing, so I am told, changes with respect to which frequencies you hear best at different volumes. Most fatigue is heard in the treble or upper mids at loud volume.