Can a fuse affect sound quality in my Classe Amps

Classé amps are not well designed ? All amps have either a line fuse or circuit breaker on the AC mains.

He probably doesn't think that improving the voltage/current through the PS(or fuse) can positively affect the presentation of an amplifier. Most don't recognize that the power supply IS indeed directly in the "signal path" of the power amp. Every gain device/stage in an amp passes voltage from the PS to the next stage(as modulated by the signal). Then the output devices(whether tube or transistor) take voltage/current(as modulated by the signal) from the PS and connect it to the speakers. That's why it doesn't take much upgrading of power supplies, power cords, room wiring, etc. to yield a major improvement in an audio system's presentation.

Exactly!!

I had a pair of Classe DR 8, ran them balanced mono, and replaced the stock fuses with IsoCleans.
This is a cheap way to protect your amp and improve the sound at the same time.
Ask yourself, what protection is a cheap fuse?
How much are you willing to risk to save a few dollars?
I used to run amps without any speaker protection fuses since I read about it in the audio critic(when PA was an audio critic).
I found he was correct, fuses degrade the signal,I was lucky in over 20 years and numerous amps tube and solid state to use solid core wire cut to the length of a fuse without any problems.
No amp failures, burnouts etc.
But that is risky business, I was lucky.
When word of the IsoCleans came out I gave them a try.
Solid wire still sounds better, but this is close and much safer.
I don't bypass fuses anymore, I use HiFi tuning in my current amp and so I can't say if it is better or worse than an IsoClean.
Treat yourself,you deserve it.
You could spend $60.00 on worse things that won't improve your sound and protect it as well as a quality replacement fuse.