Audphile1-
Glad VAC is at least on your list - tell Kevin "Harve says hi" if you talk to him. In answer to your questions - I tried both SE and balanced from my APL-modded Denon 3910 to the Preamp. SE sounded better in my system, which is not surprising since the APL was designed to sound the best single-ended (Alex Peychev, the designer, is not a big believer in balanced ICs from the source).
I also tried SE and balanced from the VAC to DNA-500, but there was a complication since there is a "Steridian"(a/k/a proprietary equalizer-type box) between the preamp and amp for my Whisper speakers (which really does work, most of the time.....)Anyway, what I discovered was that the Steridian processed a SE signal more cleanly and with more energy than it did a Balanced signal, in my system. I know that may not make much sense, because it didn't to me either, but it is/was a peculiarity of the Steridian design (among several others, which is off topic). Legacy has since replaced this problematically-engineered box with another much more expensive(Thousands $$) equalizer that supposedly doesn't have such problems.
Since SE worked the best in my system, as discussed above, those are the cables I invested in. I got a SE Virtual Dynamics Revelation Signature IC for the Denon-VAC conncetion and a combination of VD Revelation and Nirvana S-X Ltd, both SE, between the VAC Phi-Steridian-DNA-500. I tried easily 20 different IC combinations, mostly from John at the Cable Company, before arriving at my current set-up. Yes, cables DO INDEED make a difference in a resolving system!
I added bi-wired Revelation speaker cables and am now as close to my "that's it - I'm done" as I am going to get for the foreseeable future. As I said, the sound is just incredible, both to my ears and others who have listened. I am now simply, finally, ENJOYING THE MUSIC!!!
Hope this helps..........