Treat your system as an electrical installation to be managed, not just equipment to be used and it will keep you safe. Remember that audio equipment is subject to rigorous safety testing but it is NOT assumed to be in continuous use Fridges/Freezers et al are designed to operate continuously but even these are NOT without risk Just that they undergo comprehensive endurance testing to risk manage failure probability.
My system in the UK has a type 2 surge protection system on the main distribution cabinet. I fuse my individual equipment via UK type 3 pin plugs at 5A Tube Pre /5A Tube Power/ 5A Lumin X1 PSU/ 3A Mober TT PSU/Speed Controller/ 3A ifi Optical Converter PSU. I juice the power amp directly to the wall socket as well as the iFi PSU the rest is powered via a Tacima 6 way surge /RF protector. My REL'S are powered directly from mains sockets the plugs are fitted with 5A fuses.
My regime is Tube Pre and Tube powered off unless being listened to warm up time 20 mins same as REL's. I use streamed music in my warm up. The Lumin X1 PSU continually powered, although I am considering the off switch for the Lumin X1 PSU also. Optical Fibre converter Always on. Everything else is off unless used. Once warmed up the system sounds fantastic an well worth the wait.
In my opinion no Tube electronics should remain on unattended. there are only marginal gains if at all from leaving a system powered on as opposed to allowing it to warm up when powered up. There are definite disadvantages in reduced component life spans an tube life for Vacuum tube systems and questionable advantages to for solid state amps streamers/DAC's etc. over warm period from cold.
Each to his/her own I guess but weighing up the pros and cons including safety for continual powering devices that were not really designed to be continually powered I am in the switch it off camp.