@lanx0003 It turns out that GoldenSound conducted testing in 2021 and advised audiophiles not to daisy-chain DDCs.
And he is correct. That would be weird, with each successive DDC reclocking the audio. Using one (or more) USB isolator(s) ahead of a DDC however, is a viable idea, and may improve the performance of said DDC.
USB isolators are oftentimes referred to as "reclockers," but the only clocking is the 8 kHz USB packet protocol. No matter how may isolators are in series, the audio bits are clocked only once - inside the DAC.
Some report that daisychaining USB isolators helps. This seemed unusual to me as well, and I experimented with it, but it didn’t seem to bring further improvement in my system. It may be dependent upon how much high frequency noise is present. Numerous system specific variables are in play here.

