As long as you can give the Orefeo's some breathing room to the rear and don't crowd the one speaker to close to the wall they should work fine in your room. As to whether or not they will work with the amplifier you have driving the Cantabile's is another story but it is certainly worth a try. I have easily driven the Bliss Jubilee and Abcisse Jubilee in a 9'x17'x26' room with an EL-34 amp. The main concern for me with the swap if you have not had a chance to listen to the Orfeo in person is whether or not you will be ok with the change from the soft dome tweeter of the Bliss to the AMT of the Orfeo, Though both of my Reynaud's are trully excellent speakers I have a decided preference for the presentation of the Bliss Jubilee. I had a friend who owns the Bliss Jubille's with Magic Stands accompanied by twin subs. He recently had the Orfeo Grande's in his house for over three weeks, While he appreciated all of the things the OG's can do in terms of bass depth, size of the presentation and scale that the Bliss' can't do in the end he decided to stick with the Bliss/sub combo and pass on the OG upgrade. The deciding factor to him was the presentation of the Bliss tweeter. So from my perspective it comes down to the difference in presentation of the Bliss/Cantabile vs the Abscisse/Orefeo line and if your current amp is not sufficient to drive the Orfeo's are you prepared to move to a bigger tube amp.

