From other threads, I know that you are interested in Audio Note AN-J speakers. That is a terrific choice, in my opinion, and they can be used with lower-powered tube gear. However, much depends on the size of your room, how loud you want to play the system, type of music, and how much you can accept that you may not be able to play certain music at very high volume levels.
I like the 45 tube a lot. It is my favorite among the three most common low-powered triode tube (45, 2a3, 300B). I run speakers that are more efficient than yours and I don't listen at high volume levels, but I heard some effects of compression with 45s running in pushpull configuration (about twice as powerful as 45s in single ended operation). Strangely, this was most obvious with acapella mass choral music (e.g., Rachmaninov's Vespers). If you go with a 45 SET amp, you will face much more severe restrictions on volume level. But, I can easily see someone, myself included, who could live with that if the sound is otherwise to my liking.

