I am not sure how much difference you will hear on the Wyred4Dound Sx1000R compared to the stereo version.
But on audiophile level equipment the difference in sound quality is subtle but important. I lived with both two Audio Research Reference 160m and a Reference 160s for two years. The soundstage is bit wider and deeper and instruments therefore more separated on the monoblocks. The sonic characteristic are exactly the same. However, the individual impact of the instruments is slightly less. I think that is because you still have the same power but spread over a smaller three dimensional space. I have heard from a number of other owners of high end amps that this is exactly the differences they had heard as well.
For me, the two monoblocks are superior to the stereo version... I think the difference in price tag was about $10K. Reflecting two cases and additional labor. Why more people don’t do it is the cost.
So the trade off is what sonic quality can you get if you took the difference between the stereo version and the monoblock versions and just buy a better amp, Until you get pretty high the answer is usually buy a better amp,

