I think the biggest benefit of monoblocks is the separate transformers and power supplies. If properly done it will provide more control and less noise to the speaker.
What no one mentioned is there is also another class called dual mono that combines 2 mono blocks into a single chassis.
The biggest differences in all of the above are the space and cabling costs (power, speaker, line level). Your space and environment may be the biggest factor that determines what works for you.

