Dump the DDC.
Use the external clock into the DAC., test sine & square, use USB from your streamer.
With USB the DAC's clock (with the help of the external clock) is in charge and you do not have the inherent problems of IIS - with IIS the clock signal is transmitted from the source through the cable - and attaching the external clock to the DAC will not save you from the jitter occurring over IIS connection, the DAC's clock is not used.
Using IIS as a digital interconnect seems to me to be fundamentally flawed - the clock signal is being transmitted over (at least) .5 meters - the connection was designed to transfer data between on board chips!
USB buffers the data and clocking is completely handled by the DAC.

