In which part of the rectangular room the system will be located is pertinent. In an area facing a short wall in a rectangular room, I would first consider the most practical placement of the speakers within this area that minimizes boundary interactions with the front and side walls, as this is usually a limiting factor and ultimately determines ideal listening distance. One should try to get at least 1m of distance between the tweeter and those boundaries if possible. After determining speaker placement with respect to adjacent walls, measure the distance between the tweeters. Multiply that distance by 1.2 as per Jim Smith’s observations mentioned previously, and that should give the distance from tweeter-to-ear on each side. Toe the speakers in as necessary to give the most even response (REW helps tremendously). Mark this position with painter’s tape if further tweaking is desired, but this should get one close to an ideal position.