@audio-b-dog With a USB connection into your Moon 280D, the data stream is asynchronous (untimed) until it reaches the DAC’s internal clock. With Toslink/coax/AES EBU/I2S, the source device (e.g. your CD player) holds the master clock, and the data transmitted to the DAC is synchronous (timed). Clock quality is most certainly a factor in the overall result, and another variable to consider as to why one type of connection to a DAC can bring a different result than another.
The proper characteristic impedance for both coax cable and connectors is 75 ohms. Audio RCA connectors are typically 20-50 ohms, so a better coax cable will use connectors of the correct impedance. Proper impedance minimizes unwanted reflections. Where one is flexible about cable length, 1.5m (~5ft) coax cable length has been demonstrated as theoretically "ideal" for reflection mitigation. Splitting hairs possibly, but worth a mention.

