Attention Horn Owners

As I mentioned above, I have not heard your amps, but the description suggests that it is very well done--the construction is good, it uses an interstage transformer to help drive the 300B properly, etc.  Nonetheless, if you find the sound is not quite what you want, it is worth exploring alternatives.  I would not automatically assume it is the speaker that should be replaced, particularly since it is not that easy to find speakers that have all of the positive attributes of the AN-E.  I would at least try different speaker placement, room treatments, perhaps different tubes in the amp, even different amps if you can find loaners.  In looking at different amps, don't automatically assume that SET amps are "magical" and cannot be touched by other topologies.  I've heard great pushpull amps that also sound great with high efficiency speakers and OTL amps that also deliver killer sound.  

At Deja Vu, I've heard the AN-E's with Synthesis Audio amps (pushpull KT66) and prefer them over Audio Note amps because they have a punchier sound.  Perhaps you can find something like that to try.  

Sns, I use 4 Western Electric, Telefunken as my 6v6 and 2 6sn7 Raytheon’s as the I put tubes(supposed to be bass heavy). In the preamp I use 2 Raytheon and 2 RCA’s. I really love the sound of this particular set up. I’ve tube rolled a bit and found this arrangement quite nice. 

Larry. My first tube amp from Vu was a Synthesis push pull el84 amp. It had that punch for sure. I matched it with Zu Soul Supreme speakers and had extreme ear fatigue really quickly. Headache would last hours. I tried all sorts of treatments around the room. In my rush to find a fix, I sold the Zu’s and decided to sell the amp as well. The amp had to be biased by hand, by going in with a screw driver next to that power storing transformer! It also had a built in dac. At the time, I wanted to play around with various sounding dacs and find one that really was my sound. So off it went. That Synthesis a-40 gets great reviews but same situation. 
So, depending on trade in or personal sale, I may try the Soro se signature or scrap tubes and try a Pass Labs int-60. Both are 1 box solutions. 

Btw sns, I might be leaning towards the Kef kc-92. I’d like to start with one sub and the dual opposed provides a bit more. More research before I pull the trigger though. I’m an impulsive person when it comes to these things but amp sale or trade in forces me to slow down. That process will dictate the direction I head I suppose. 

I have never heard a Zu speaker that I could stand--very bright, lean and harsh sounding.  I think it gets attention because it is extremely lively sounding, and that is a BIG contrast with most modern speakers which tend to sound lifeless.