The KEF dealer here is a rather low end store that mainly caters to home theater. The store doesn't have dedicated audio rooms so its a waste of time to try listening to anything in the store because of the ambient noise.

I have a pair of B&W CM5 S2 that are bright enough that I feel fatigue if I listen for an extended period of time.  Please will someone tell me what is the overall character of the LS50?  If I am looking for a speaker that isn't quite so bright is the LS50 something I should consider?

I use my non-meta LS50's with very neutral gear and have zero fatigue. I listen a lot of hours while I work.

The speakers will go into storage on Saturday to move in my new speakers, but I will never sell them, just love them. 
Yup no fatigue with old Ls 50s and not expecting any with the metas either based on limited audition and reviews to date. 
I’m going off of memory but I believe the original LS50s have a bump around 12k that could be bright to those under the age of say 35.