For maybe the first 10-15 years of my audiophile "career" I heard differences between anything and everything. Cable lifters, signal cables, speaker cables, power cables, isolation devices, that green CD pen, you name it. I heard the differences at shop demos, at my friends’ places and at home.
Then real stuff happened and I lost interest in HiFi completely for a couple of years or so. When I came back I heard none, or almost none, of it. Not, I hasten to add, because I’d lost my hearing in the meantime. It is and has always been excellent. I have no problem picking up and pointing out slight nuances between cartridges, tone arms, CD players, amplifiers and whatever else which *ought* to sound different - but all that other stuff all sound the same or make no difference whatsoever.
I’ve given this quite some thought and the one change from before to after that I can point to as an explanation is that I no longer give a s**t. I no longer want, need or expect things to sound different and so, apparently, many of them don’t.
That’s my personal experience anyway. Take it as you will.