Making any part of it 'audio grade sound' will be a waste of money since you are dealing with 'in prefect' spaces that are not suitable to hi end sound.
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I was thinking of Sonos.... seems like I can just install the speakers in the locations I want in the house, run the speaker wires to a central closet location and then build up from there. Start w/ 1 Sonos Connect Amp and then build up.
The other option is going with a system that does FULL home automation like ELAN.. however, this is expensive but it does much more than just audio. It'll do lights, alarm/security, video surveillance, thermostat, etc.