I've tried Squeezebox both wired (CAT 5)and wireless. Sound quality was identical as far as I could tell. The only real world difference was that with the wireless, everytime I used the Microwave, I would lose the signal. I've heard that with some wireless phones, the same thing happens. So I switched to wired.
I use EAC, but I compress using FLAC losseless compression (which is supported by Squeezebox) and 200 CDs takes about 65-70 gb. So if you wanted to do it completely uncompressed, I would guestimate that it would take about 35% more space -- close to 90 to 100gb per 200 uncompressed CDs. If someone has actually ripped 200 uncompressed, hopefully they'll chime in with the actual HD space used.
Good Luck.