"There is complex interaction among amp/speakers/speaker cable. "
Nothing complex about this, it is all about opening up so the amp can breathe freely. And there is only one way to do it right, hook up some thick solid core copper conductors..
How much is enough? No power-conductor on the secondary site should be less than 9awg on smaller systems, 7awg on a fullrange system. Bi- and tri-wiring opens up a good system quite a bit.
OldHvyMec, you`re on the right track with your thinking.