Generally speaking, the more you toe-in speakers, the more solid and precise the center image will seem, but, this comes at the expense of a less expansive (wide) soundstage. You need to experiment, that is the only way to know what is right for your situation and personal taste. the same actually goes with all aspects of speaker and listening position placement--a lot of trial and error is required. Don't for get to also dial in speaker height and rake angle (how much the speaker is tipped backwards (i.e., the degree to which it is angled toward the ceiling).
Question about speaker angle
I've always been under the impression that your front main speakers should be angled so that the "face" of the speaker is basically perpendicular with the listener's face when viewing the speakers from the sweet spot. I do however see others placing the speakers parallel or inline with the surface of the wall behind the speakers. I'm wondering, how much loss to the sonic sound stage this creates.