Mixed driver tube for Mcintosh MC275

I just wonder if anybody know which sections of Mcintosh MC275's driver tube are most crucial? Is it all sections of equipment are the same in terms of the importance of the driver tubes. Another thing, is it using a tube that has a sonic trait that is different than another like combining a thinner more detailed tube like a Telefunken can actually work very well with a warmer tube like a Mullard?