Home Depot speaker cable, which one to buy

As long as you get as pure a copper cable as possible and the largest gauge you can handle, there will be little difference. I have tried several lawn and garden extension cords and didn't like them. They sounded weak and muddied. If you are going to go for the less expensive variety I recommend Canare 4S11. I really like the anti-cables but decided to go for short ICs and long speaker cables, thus the 4S11.