Advice on 3 different system combination

Hi guys, Here are 3 different systems that i've put up together from reasonably priced to very expensive.
The speakers don't change, the source is only network streaming for high res files at the moment.
Room size is 15'x21' long.

System n° 1 : ASR Emitter II Exclusive
Ayon S5 network player
Thiel CS 3.7

System n° 2 : Karan KAS 600 stereo amp
Karan KAL Reference MK3 preamp
Ayon S5 network player
Thiel CS 3.7

System n° 3 : Karan KAS 600 stereo amp
VAC Signature MKIIa preamp
MSB Diamond DAC IV Plus with network renderer
Thiel CS 3.7

Please comment if you have any experience with this gear.
Would system n° 3 be a significant upgrade compared to system n° 1 or would the price difference not be worth it ?
Any advice, comments and gear suggestions are welcome.